Ongoing projects in the laboratory include:
- Engineering and validation of conditional (floxed) zebrafish mutants. We are using our oligonucleotide- mediated CRISPR/Cas9 genome editing to insert loxP sites into the zebrafish genome. Floxed alleles are crossed to various CreERT2 drivers to achieve tissue-specific loss of function.
- Engineering and validation of epitope-tagged transcription factors in order to understand gene regulatory programs of heart regeneration.
- Understanding the mechanisms and outcomes of CRISPR/Cas9 genome editing.